Serum 2-Methoxyestradiol, an Estrogen Metabolite, is Positively Associated with Serum HDL-C in a Population-Based Sample
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چکیده
منابع مشابه
Body Fat Free Mass Is Associated with the Serum Metabolite Profile in a Population-Based Study
OBJECTIVE To characterise the influence of the fat free mass on the metabolite profile in serum samples from participants of the population-based KORA (Cooperative Health Research in the Region of Augsburg) S4 study. SUBJECTS AND METHODS Analyses were based on metabolite profile from 965 participants of the S4 and 890 weight-stable subjects of its seven-year follow-up study (KORA F4). 190 dif...
متن کامل2-Methoxyestradiol, an endogenous estrogen metabolite, induces thyroid cell apoptosis.
The etiology of autoimmune thyroid diseases is unclear; however, the extreme female predominance suggests that sex hormones may have a pathogenic role. 2-Methoxyestradiol (2-ME) is present in the serum of women during the ovulatory and luteal phases of the menstrual cycle, and during pregnancy. We investigated the actions of 2-ME and estrogen on thyroid follicular cells. 2-ME induced dramatic c...
متن کاملAPOBEC3 Deletion is Associated with Breast Cancer Risk in a Sample of Southeast Iranian Population
Breast Cancer (BC) is considered as one of the most important causes of death worldwide. Previous studies showed that apolipoprotein B mRNA- editing catalytic polypeptide-like 3 (APOBEC3) gene deletion significantly increased the risk of BC risk in Chinese and European women. The present study aimed to assess the possible impact of APOBEC3 deletion and the risk of BC in a sample of Iranian popu...
متن کاملIs 2-methoxyestradiol an endogenous estrogen metabolite that inhibits mammary carcinogenesis?
Catechol estrogens (2- or 4-hydroxyestradiol and 2- or 4-hydroxyestrone) are chemically reactive estrogen metabolites that are O-methylated to less polar monomethyl ethers by catechol-O-methyltransferase, an enzyme present in many tissues such as the liver, kidney, brain, placenta, uterus, and mammary gland. In the present report, we review recent studies on the antitumorigenic and antiangiogen...
متن کاملInflammatory Markers Are Positively Associated with Serum trans-Fatty Acids in an Adult American Population
BACKGROUND AND AIM The relationship between serum trans-fatty acids (TFAs) and systemic inflammation markers is unclear. We investigated the association of serum TFAs with high sensitivity C-reactive protein (hs-CRP) and fibrinogen in adult Americans. METHODS The 1999 to 2000 National Health and Nutrition Examination Survey (NHANES) participants with measured data on hs-CRP and fibrinogen wer...
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ژورنال
عنوان ژورنال: Lipids
سال: 2011
ISSN: 0024-4201,1558-9307
DOI: 10.1007/s11745-011-3600-y